01
Best overall pick
Fabio's Pizza
Downtown St. Clairsville • Classic Hometown Pizzeria • Local Favorite
Fabio's Pizza feels like the small-town shop everyone in St. Clairsville grows up on, with hearty pies and a friendly, no-rush vibe.[5]
Tucked near the center of town, Fabio's leans into generously topped pizzas that are clearly built to feed families and teams after practice.[5] The crust is sturdy enough to handle lots of cheese and toppings, and the staff is used to big call-ahead orders for parties or game nights.[5]
02
Best for a quick bite
Papa D's Pizza
West Main Street • Counter-Service Slice Shop • Best For Takeout
Papa D's Pizza is a compact Main Street operation that focuses on straightforward, satisfying pies for carryout.[3][5]
With its small footprint and steady stream of locals picking up orders, Papa D's is ideal when you want good pizza without a long sit-down meal.[3][5] The menu keeps things simple—classic toppings, familiar combos, and plenty of cheese—so it is easy to call in, grab your box, and get back home or on the road.[3][5]
03
Best for sit-down dinners
Pizza Milano
National Road Corridor • Italian-American Restaurant & Pizzeria • Best For Families
Pizza Milano serves big, shareable pizzas alongside Italian-American staples in a casual dining-room setting.[4]
This is the spot when you want more than just a slice—think pizza, pastas, and hot sandwiches arriving at the table still bubbling from the oven.[4] The atmosphere is relaxed and family-friendly, making it a comfortable choice for group dinners after shopping runs or weekends in town.[4]
04
Best for groups and game nights
DeFelice Bros. Pizza
Near Ohio Valley Plaza • Regional Pizza Chain • Great For Sharing
DeFelice Bros. Pizza brings a regional Ohio Valley style to big, topping-heavy pies that are easy to pass around a crowded table.[5]
Known around the valley, DeFelice specializes in pizzas piled high with cheese and classic toppings, plus crowd-pleasing sides like wings and breadsticks.[5] Its location near the shopping area makes it convenient for picking up a stack of boxes before a game night, movie marathon, or family get-together.[5]
05
Most reliable late-night option
Domino's Pizza
Plaza Drive Shopping Area • National Delivery Chain • Best For Late-Night Delivery
The Domino's on Plaza Drive covers St. Clairsville with fast, predictable delivery and an app-driven ordering routine.[2][5]
When you want something familiar and quick, this Domino's location delivers exactly what you expect—customizable pies, specialty pizzas, and a lineup of sides like wings and cheesy bread.[2] It is especially handy for late-night cravings or hotel stays near the interstate, when sit-down spots have closed but you still want a hot pizza at the door.[2]